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REFLEX SUPPLEMENTAL TESTING - A RAPID, EFFICIENT AND HIGHLY ACCURATE METHOD TO IDENTIFY SUBJECTS WITH AN INFECTION, DISEASE OR OTHER CONDITION
REFLEX SUPPLEMENTAL TESTING - A RAPID, EFFICIENT AND HIGHLY ACCURATE METHOD TO IDENTIFY SUBJECTS WITH AN INFECTION, DISEASE OR OTHER CONDITION
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机译:补充测试-一种快速,有效且高度准确的方法来识别患有传染病,疾病或其他情况的对象
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摘要
The present disclosure concerns methods, compositions and apparatus for detecting pathogens and/or molecular markers. In a particular embodiment, the pathogen to be detected may be Mycobacterium bovis or any other Mycobacterium species that causes tuberculosis in a mammal. However, the disclosed methods are not limited and virtually any type of pathogen and/or molecular marker may be screened and detected. Preferred embodiments comprise reflex supplemental testing using the same assay at approximately 100% sensitivity and the highest possible corresponding sensitivity - in one example 70%. Such assay conditions, used iteratively, result in elimination of 70% of uninfected subjects for each round of testing. Use of 4 or more rounds of testing results in less than 1% error. Since only positive samples are retested, the methods provide a rapid, inexpensive and highly accurate way to detect infected subjects.
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