USE OF BOMBESIN/GASTRIN-RELEASING PEPTIDE ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS, ACUTE LUNG INJURY AND BIPOLAR DISORDER

摘要

The invention concerns the use of a bombesin/gastrin releasing peptide antagonist in the preparation of a pharmaceutical composition for the treatment of inflammatory and immune-mediated inflammatory conditions, in particular sepsis, acute lung injury and rheumatoid arthritis as well as for the treatment or prophylaxis of brain disorders, pref­erably bipolar disorder, and in particular the different forms and/or subforms of bipolar disorder, such as mania, acute mania, severe mania, hypomania, depression, moder­ate depression, dysthymia, severe depression, episodes of mania and/or depression, psychosis/psychotic symptoms (e.g. hallucinations, delusions), mixed bipolar state, bipolar I disorder, bipolar II disorder and/or rapid-cycling bipolar disorder. In particular, specific nonapeptides with antagonist properties against bombesin or bombesin-like peptides, such as the gastrin releasing peptide, may be used in the treatment of in­flammatory and immune-mediated inflammatory conditions as well as brain disorders.