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FUNCTIONAL BIOLUMINESCENCE ENERGY RESONANCE TRANSFER (BRET) ASSAY TO SCREEN, IDENTIFY AND CHARACTERIZE RECEPTOR TYROSINE KINASE LIGANDS
FUNCTIONAL BIOLUMINESCENCE ENERGY RESONANCE TRANSFER (BRET) ASSAY TO SCREEN, IDENTIFY AND CHARACTERIZE RECEPTOR TYROSINE KINASE LIGANDS
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机译:功能性生物发光能量共振转移(BRET)可对屏幕上的酪氨酸激酶配体进行筛查,鉴定和鉴定
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摘要
Disclosed herein are methods of evaluating whether a test compound functions as a ligand for a receptor tyrosine kinase. Also provided are methods of making pharmaceutical compositions that include agonists, antagonists, or inverse agonists of receptor tyrosine kinases. Also provides are isolated cells that include a receptor tyrosine kinase and a second protein, wherein the receptor tyrosine kinase contains a fluorescent donor moiety and the second protein contains a fluorescent acceptor moiety.
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