PHARMACEUTICAL COMPOSITIONS OF THE PEPTIDE ANGIOTENSIN-(1 -7) ANG-(I -7) AND ITS ANALOGUES, AGONISTS AND ANTAGONISTS, FOR USE IN CONTROLLING THE FUNCTIONS OF THE REPRODUCTIVE SYSTEM

摘要

The present invention relates to the use of pharmaceutical compositions of the peptide Ang-(1-7) and its analogues, agonists and antagonists, prepared by using the cyclodextrins, its derivatives, liposomes and biodegradable polymers and/or mixtures thereof and/or the derived products, mixtures thereof with excipients, as well as mixed or not mixed with other pharmaceutically or pharmacologically active principles, in controlling the functions of the human or animal reproductive system and its pathologies.lt was not found any prior art technology claiming the use of Ang- (1-7) as well as its pharmaceutical compositions, in encapsulated or non- encapsulated form, its mixtures with pharmaceutically and pharmacologically active excipients, as well as mixed or non-mixed with other pharmaceutically or pharmacologically active principles, in controlling diseases associated to the male or female reproductive system. The invention is also characterized by the use of the receptor- ligand interaction between the MAS receptor and Ang-(1 -7) and its analogues, its pharmaceutical compositions, either encapsulated or not, as a target for study and therapeutics of the reproductive functions.