METHODS, PROGRAM PRODUCT AND SYSTEM FOR ENHANCED IMAGE GUIDED STEREOTACTIC RADIOTHERAPY

摘要

Methods, program product (21), and systems (20) to enhance accuracy of radiotherapy treatment delivery are provided. An embodiment of method, for example, can include registering a three-dimensional (3D) image (53, 55) of a frame (42) fixedly connected to a rigid treatment couch (41) responsive to maximization of mutual information (MMI). The mutual information (MI) is a measure of statistical dependence between image intensities of corresponding voxels of two sets of images. The embodiment of the method also includes registering a 3D image (52, 54) of a treatment plan of anatomy after registration of the frame (42), and cropping the 3D images (52, 54), (53, 55) of each of the frame (42) and the treatment plan to first and a second preselected sizes. One of either the first or second size is larger than the other. The embodiment of the method further includes fitting by aligning the smaller image to the larger image and removing systematic error.