The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention are useful to determine metastasis-free survival of breast cancer patients. The biomarkers can be detected by SELDI mass spectrometry in serum samples fractionated by means of anion exchange chromatography. Some of the biomarkers have been identified as : Apolipoprotein A 1; Apolipoprotein A 2; Haptoglobin alpha 1; Transferrin; Complement C 3 a; and truncated forms thereof .
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