METHODS AND COMPOSITIONS DIRECTED TO DJ-1 AS REGULATOR OF THE ANTI-OXIDANT TRANSCRIPTION FACTOR NRF2

摘要

The present invention provides compositions and methods related to the field of oxidative stress in cells. The present invention provides compositions and methods for manipulating and assessing DJ-1 and Nrf2 activity, thereby affecting an oxidative stress response. The present invention also provides methods for treating diseases and disorders associated with an altered oxidative stress response.