YIN YANG 1 AS A TREATMENT FOR CARDIAC HYPERTROPHY AND HEART FAILURE

摘要

The present invention provides for methods of treating and preventing cardiac hypertrophy and heart failure. The present invention provides a link between YYl regulation of fetal gene expression in cardiomyocytes that includes interactions with class II HDACs, ERK1/2 and CaMKII. The present invention further demonstrates that YYl can repress ERKl/2-mediated fetal cardiac gene induction that leads to cardiac hypertrophy.