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MEASUREMENT OF GAIT DYNAMICS AND USE OF BETA-BLOCKERS TO DETECT, PROGNOSE, PREVENT AND TREAT AMYOTROPHIC LATERAL SCLEROSIS
MEASUREMENT OF GAIT DYNAMICS AND USE OF BETA-BLOCKERS TO DETECT, PROGNOSE, PREVENT AND TREAT AMYOTROPHIC LATERAL SCLEROSIS
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机译:步态动力学的测量和β受体阻滞剂的检测,预后,预防和治疗肌萎缩性侧索硬化症的使用
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摘要
The present invention, at least in part, provides methods of improved early diagnosis of neurodegenerative disease, e.g., ALS, in a subject via measurement of the gait dynamics of the subject (e.g., via the exemplary ventral plane videography methods disclosed herein). The present invention also provides for administration of a beta-adrenergic blocking agent (beta-blocker) to a subject at risk of developing ALS (e.g., a SODl G93A mouse) and/or having early stages of ALS, to modulate supranormal gait characteristics and to prevent, treat and/or ameliorate the onset, advancement, severity or effects of a neurodegenerative disease, e.g., ALS, in the subject.
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