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TARGETING TNF-ALPHA CONVERTING ENZYME (TACE)-DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
TARGETING TNF-ALPHA CONVERTING ENZYME (TACE)-DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
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机译:针对肿瘤治疗中靶向TNF-α转化酶(TACE)的依赖生长因子
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摘要
The invention provides methods for modulating tumor cell proliferation by contacting a cell (e g tumor cell) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the TACE inhibitor enhances the sensitivity of the cell to the EGFR tyrosine kinase inhibitor Additionally, methods for treating cancer and methods for identifying TACE inhibitors are also provided
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