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AMPHIPHILIC DIBLOCK, TRIBLOCK AND STAR-BLOCK COPOLYMERS AND THEIR PHARMACEUTICAL COMPOSITIONS

机译:两性双嵌段,三嵌段和星形嵌段共聚物及其药物成分

摘要

This invention relates to novel amphiphilic diblock, triblock copolymers and star-shaped block copolymers comprising a biodegradable polymer covalently attached at the polymer ends, to a hydrophilic vinyl polymer, via divalent sulfur atom; to a process for producing the block polymers; to a polymerization process which comprises subjecting the monomers capable of radical polymerization to radical polymerization in the presence of a macromolecular biodegradable chain-transfer agent; and to pharmaceutical compositions comprising the block copolymers loaded with therapeutic agents.
机译:本发明涉及新颖的两亲性二嵌段,三嵌段共聚物和星形嵌段共聚物,其包含在聚合物末端通过二价硫原子共价连接至亲水性乙烯基聚合物的可生物降解的聚合物。用于生产嵌段聚合物的方法;本发明涉及一种聚合方法,该方法包括在大分子可生物降解的链转移剂的存在下使能自由基聚合的单体进行自由基聚合。本发明涉及包含负载有治疗剂的嵌段共聚物的药物组合物。

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