PHARMACEUTICAL COMPOSITION OF MORPHINE IN READY-TO-USE INJECTABLE SOLUTION FORM AND SINGLE DOSAGE FORM OF MORPHINE FOR EPIDURAL OR INTRATHECAL ADMINISTRATION

摘要

The present invention refers to an analgesic composition in the form of an injectable solution, sterile and apyrogenic, which is constituted by a pharmaceutically acceptable morphine salt dissolved in a pharmaceutically acceptable solvent (carrier), wherein the pH of the resulting solution is from 2.5 to 6.5 and the morphine concentration is from about 0.025 to 0.195 mg/mL (expressed as the hydrated salt thereof). Such composition, packed in a sealed container is ready-to-use and suitable for epidural and intrathecal administration in adults and intravenous in children.