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1,3-DIACLYATED,26,27-ALKYL/HALOALKYL VITAMIN D sb 3 /sb COMPOUNDS AND METHODS OF USE THEREOF
1,3-DIACLYATED,26,27-ALKYL/HALOALKYL VITAMIN D sb 3 /sb COMPOUNDS AND METHODS OF USE THEREOF
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机译:1,3-丁二酸,26,27-烷基/卤代烷基维生素D sb 3 / sb化合物及其使用方法
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摘要
The invention provides 1,3-di-acylated vitamin DSUB3 /SUBanalogs of cholecalciferol, substituted at carbon-20 with methyl or cyclopropyl wherein carbon-16 is a single or double bond, and carbon-23 is a single, double, or triple bond. Various alkyl or haloalkyl substitutions are incorporated at carbon-25. The invention provides pharmaceutically acceptable esters, salts, and prodrugs thereof. Methods for using the compounds for the prevention and treatment of uveitis are also disclosed.
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