DRUG DISCOVERY FOR NEURODEVELOPMENTAL DISORDERS AND THEIR COMPLICATIONS

摘要

The invention relates to a method for identifying compounds which alter the activity of gamma-secretase, comprising provision of a collection of compounds; contacting the compounds of the collection with a cell line or organism expressing gamma-secretase; measurment of the gamma-secretase activity in the cell line or organism before and after the contact with the compound; and identification of the compounds in the collection that modulate the gamma-secretase activity of the cell line or organism. More in particular, the gamma-secretase that is expressed by the cell line or organism is a variant gamma-secretase, the activity of which is altered, in particular decreased, as compared to the gamma-secretase activity found in a human not carrying the SNP651 or carrying the wild- type Aph-lb gene.