INCLUSION COMPLEXES OBTAINED BY USING A PROCESS WITH SUPERCRITICAL CO2 AND AN AGENT FOR INTERACTION WITH THE COMPLEX

摘要

Soluble inclusion complex comprising one or several active substances difficult to dissolve in aqueous medium including one or several host molecules and piroxicam-cyclodextrin-arginine in which the level of solubilization of piroxicam in solution containing 4 g/liter piroxicam in water, measured at 37[deg]C with agitation over 5-120 minutes is higher than 90%, most especially higher than 99%. INDEPENDENT CLAIM are included for: (1) preparation of the complex involving:contact with host molecules, initation of molecular diffusion, recovery of the soluble inclusion compound formed; (2) a pharmaceutical composition containing the complex.