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MODULATION OF CELL INTRINSIC STRAIN TO CONTROL CELL MODULUS, MATRIX SYNTHESIS, SECRETION, ORGANIZATION, MATERIAL PROPERTIES AND REMODELING OF TISSUE ENGINEERED CONSTRUCTS
MODULATION OF CELL INTRINSIC STRAIN TO CONTROL CELL MODULUS, MATRIX SYNTHESIS, SECRETION, ORGANIZATION, MATERIAL PROPERTIES AND REMODELING OF TISSUE ENGINEERED CONSTRUCTS
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机译:调节细胞内源性应变,以控制组织工程结构的细胞模量,基质合成,分泌,组织,材料特性和重塑
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摘要
The present invention provides methods for manipulating the intrinsic strain of cells by treating tissue engineered constructs or native tissue with compounds which affect the intrinsic strain setpoint of the cells in order to modulate matrix synthesis, secretion, organization and/or remodeling so that the tissues withstand in vivo mechanical forces and have the structural characteristics of host tissue which has been permanently altered by injury, atrophy or disease. The compounds include binding site peptides, ATP, UTP and related analogues, IL-1βb, TGF-α, cytochalasin D, hyaluronic acid, nocodazole and others. Also provided are methods for applying a mechanical external strain to the tissues, as well as methods for modulating the expression of cytoskeletal genes that transcribe cytoskeletal proteins which regulate a cell's intrinsic strain setpoint.
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