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PREVENTION AND TREATMENT OF VASCULAR DISEASE WITH RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS ENCODING APOLIPOPROTEIN A-I AND APOLIPOPROTEIN A-I MILANO
PREVENTION AND TREATMENT OF VASCULAR DISEASE WITH RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS ENCODING APOLIPOPROTEIN A-I AND APOLIPOPROTEIN A-I MILANO
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机译:载脂蛋白A-I和脂蛋白A-I的重组腺病毒结合病毒载体对血管疾病的预防和治疗
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摘要
Described herein is a gene therapeutic approach to the prevention and treatment of vascular disease and coronary heart disease; in particular, atherosclerosis. The inventive methods may be used in the prevention and treatment of atherosclerosis, as well as any disease or physiological condition in which atherosclerosis plays a role. The inventive methods involve the gene delivery of ApoA-I or ApoA-IMilano. This may be accomplished by the use of rAAV technology. rAAV virions may be delivered to a mammalian subject by various methodologies, including transplantation of transduced bone marrow cells, direct intramuscular injection, intravenous or portal vein injection or stent delivery.
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