METHODS AND SYSTEMS FOR EVALUATING INTERACTION OF MEDICAL PRODUCTS AND DEPENDENCE ON DEMOGRAPHIC VARIABLES

摘要

Methods of evaluating interaction two or more medical products or conditions, in the context of a reference condition are provided. They method may include developing a reference contingency lattice of lattice subsets from a subset of the patient records containing the reference condition, wherein the lattice subsets correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof. Orthogonal lattices may be used. Alternatively or in addition, a multi-way interaction analyses may be performed that may permit the elimination of arbitrarily strong second-order bystander effects. A two-way interaction analysis may permit the examination of the influence of demographic variables like age or gender on drug/adverse event associations.