TNF ALPHA NGF MOLECULAR SWITCH FOR DETERMINING CELL FATE

摘要

The invention relates to compositions that affect flux through signaling pathways downstream of receptors TNFR2 and TrkA, respectively. Such compositions are useful for altering the balance between proliferation/survival and differentiation in a cell, and thus for influencing cell fate. We propose a new surprising approach for the treatment of neuroblastoma and other diseases, comprising inhibiting TNFα signaling and promoting NGF signaling.