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Method for detection and localization of genes in situ using branched-DNA hybridisation
Method for detection and localization of genes in situ using branched-DNA hybridisation
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机译:利用分支DNA杂交原位检测和定位基因的方法
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摘要
Methods are provided for highly sensitive and rapid in situ detection of a nucleic acid analyte of a known sequence. The method employs oligonucleotide probes in a series of optimized steps to amplify a signal and decrease background. Sensitivity is enhanced such that the method can detect as few as 1–2 copies of nucleic acid analyte per sample, the sample containing a cell, tissue or similar biological material. Methods of detecting and identifying the position of the nucleic acid analyte in a cell are also provided.
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