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A HYPERSPECTRAL MICROSCOPE FOR IN VIVO IMAGING OF MICROSTRUCTURES AND CELLS IN TISSUES
A HYPERSPECTRAL MICROSCOPE FOR IN VIVO IMAGING OF MICROSTRUCTURES AND CELLS IN TISSUES
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机译:用于组织成像和细胞体内成像的超光谱显微镜
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摘要
An optical hyperspectral/multimodal imaging method and apparatus is utilized to provide high signal sensitivity for implementation of various optical imaging approaches. Such a system utilizes long working distance microscope objectives so as to enable off-axis illumination of predetermined tissue thereby allowing for excitation at any optical wavelength, simplifies design, reduces required optical elements, significantly reduces spectral noise from the optical elements and allows for fast image acquisition enabling high quality imaging in-vivo. Such a technology provides a means of detecting disease at the single cell level such as cancer, precancer, ischemic, traumatic or other type of injury, infection, or other diseases of conditions causing alterations in cells and tissue microstructures.
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