GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS

摘要

The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is -COSUB2/SUBH, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and RSUP1 /SUPand RSUP2 /SUPare each independently selected from the group consisting of: CSUB1-6/SUBalkyl and CSUB3-6/SUBcycloalkyl, as well as pharmaceutical composition comprising said compounds and methods of using said compounds. The compounds of the present invention lower the level of AbetaSUB42 /SUBand are therefore useful for preventing, delaying or reversing the progression of Alzheimer's Disease.