FORMULATION COMPRISING OF CEFTAZIDIME, TAZOBACTAM AND LINEZOLID

摘要

The present invention is to provide a pharmaceutical composition of Ceftazidime and Tazobactum in fixed dose combination with Linezolid in Injectable dosage form. Tazobactum in the composition acts as Enzyme Inhibitor that enhances the antibacterial activity of Ceftazidime by inhibiting Betalactamases such as, Group 1 Cephalosporinases, Group 2br TEM-Betalactamases and Group 3 Metallo- Betalactamases. The active ingredients are basically Betalactam antibiotics, selected from Ceftazidime and combined with Tazobactum. Besides, the composition containing Ceftazidime and Tazobactum is combined with yet another drug, Linezolid, an Oxazolidinone, a new class of antibacterial, with exceptionally good activity against MRSA, VRSA, E.faecalis and Bacteroides, wherein, Ceftazidime exhibits weaker activity. The present invention is envisaged to have a useful role in Critical conditions as an empiric therapy