Sustained release pharmaceutical composition free of food effect and a method for alleviating food effect in drug release

摘要

The invention provides a sustained release composition free of food effect comprising:(c) a core comprising an active ingredient except carbamazepine and verapamil; and(d) a functional coating comprising, based on the weight of the coating, from 30 to 80% of a gastroresistant polymer and from 10 to 40% of a hydrophilic silicon dioxide.;The invention also provides a method for alleviating food effect in a pharmaceutical composition.