首页>
外国专利>
TARGET PROTEIN OF ANTIDIABETIC AGENT AND NOVEL ANTIDIABETIC AGENT INSUFUL CORRESPONDING THERETO
TARGET PROTEIN OF ANTIDIABETIC AGENT AND NOVEL ANTIDIABETIC AGENT INSUFUL CORRESPONDING THERETO
展开▼
机译:抗糖尿病药的靶蛋白和相应的抗糖尿病药的靶蛋白
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is intended to elucidate a molecular target of an antidiabetic such as a thiazolidine derivative. The present invention provides a screening method for an antidiabetic, comprising the steps of: bringing a candidate substance to be screened into contact with a protein represented by the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 with the deletion, substitution, addition, or insertion of one or plural amino acids and interacting with the antidiabetic; and detecting the interaction between the candidate substance and the protein.
展开▼
机译:本发明旨在阐明抗糖尿病药例如噻唑烷衍生物的分子靶标。本发明提供了抗糖尿病的筛选方法,其包括以下步骤:使待筛选的候选物质与以下(a)或(b)表示的蛋白质接触:(a)包含氨基酸序列的蛋白质由SEQ ID NO:2表示; (b)一种蛋白质,其包含衍生自SEQ ID NO:2所示的氨基酸序列的氨基酸序列,且具有一个,多个氨基酸的缺失,取代,添加或插入,并且与抗糖尿病药相互作用。以及检测候选物质与蛋白质之间的相互作用。
展开▼