The invention provides compounds of the formula (I); or salts or solvates or N-oxides thereof; wherein: RSUPq /SUPis selected from groups (a), (b) and (c); the asterisk denoting the point of attachment to the pyrazole ring; X is N or CRSUP5/SUP; X'' is NRSUP4/SUP; O, S or S(O); A is a bond or -(CHSUB2/SUB)SUBm/SUB-(B)SUBn/SUB-; B is C-O, NRSUPg/SUP(C-O) or O(C-O) wherein RSUPg /SUPis hydrogen or CSUB1-4 /SUBhydrocarbyl optionally substituted by hydroxy or CSUB1-4 /SUBalkoxy; m is 0, 1 or 2; n is 0 or 1; RSUP0 /SUPis hydrogen or, together with NRSUPg /SUPwhen present, forms a group -(CHSUB2/SUB)SUBp/SUB- wherein p is 2 to 4; and RSUP1 /SUPto RSUP6b /SUPare as defined in the description. Compounds of the formula (I) have activity as inhibitors of CDK, aurora and GSK-3 kinases are useful in treating or preventing diseases such as cancers that are mediated by the said kinases.
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机译：本发明提供式（I）的化合物;或其盐或溶剂化物或N-氧化物;其中：R q 选自（a），（b）和（c）组;星号表示与吡唑环的连接点; X是N或CR 5 ; X''是NR 4 ; O，S或S（O）; A是一个键或-（CH 2 ） m -（B） n -; B是CO，NR g （CO）或O（CO），其中R g 是氢或任选被羟基取代的C 1-4 烃基或C 1-4 烷氧基; m为0、1或2; n为0或1; R 0 是氢或与NR g （如果存在）形成基团-（CH 2 ） p -其中p为2至4; R 1 至R 6b 如描述中所定义。式（I）化合物具有作为CDK，极光和GSK-3激酶抑制剂的活性，可用于治疗或预防由所述激酶介导的疾病，例如癌症。
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