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BIFUNCTIONAL ANTIBIOTICS FOR TARGETING RRNA AND RESISTANCE CAUSING ENZYMES AND FOR INHIBITION OF ANTHRAX LETHAL FACTOR
BIFUNCTIONAL ANTIBIOTICS FOR TARGETING RRNA AND RESISTANCE CAUSING ENZYMES AND FOR INHIBITION OF ANTHRAX LETHAL FACTOR
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机译:靶向RRNA和抗药性酶的双效抗生药,并能抑制蒽环致病因子
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摘要
A novel group of aminoglycosides which share some structural features of currently available aminoglycosides, while also having significant structural differences, is disclosed. The similarity enables these aminoglycosides to be highly potent and effective antibiotics, while the significant differences enable these aminoglycosides to reduce or even block antibiotic resistance. Use of such aminoglycosides, as well as other aminoglycosides which share some structural features of currently available aminoglycosides for inhibition of anthrax lethal factor, and hence as a cure for anthrax is also disclosed.
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