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A DOUBLE-LAYER DOSAGE FORM CONTAINING VITAMIN C AND COMMON COLD THERAPEUTIC AGENT AND A METHOD OF PREPARING THE DOSAGE FORM
A DOUBLE-LAYER DOSAGE FORM CONTAINING VITAMIN C AND COMMON COLD THERAPEUTIC AGENT AND A METHOD OF PREPARING THE DOSAGE FORM
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机译:包含维生素C和普通感冒治疗剂的双层剂量形式及其制备方法
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摘要
A double-layer dosage form containing vitamin C and a common cold therapeutic agent, and a method for preparing the same dosage form are provided to improve physical stability of vitamin C and common cold therapeutic agent by separately tabletting them in the dosage form, and coating the dosage form, and enhance patient's compliancy by coating the first coated dosage form with sweetener and flavoring agent. The double-layer dosage form contains vitamin C granules in a first layer and a common cold therapeutic agent in a second layer, wherein the double-layer dosage form is double-coated with a first transparent coating layer and a second coating layer containing sweetener and flavoring agent; the transparent coating material is at least one selected from polyvinyl alcohol(PVA), hydroxypropylmethylcellulose(HPMC), phthalic acid hydroxypropylmethylcellulose(HPMCP) and meta-acrylic acid dimethylaminoethyl/meta-acrylic acid methyl copolymer(Eudragit E); the sweetener is selected from acesulfame potassium, aspartame, stevioside, sucralose and saccharin; and the flavoring agent is prepared by dissolving volatile aromatic oil in alcohol.
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