USE OF MODULATORS OF A NOVEL FORM OF MUSCLE SELECTIVE CALCINEURIN INTERACTING PROTEIN (MCIP-1-38) AS A TREATMENT FOR CARDIOVASCULAR DISEASES

摘要

The present invention describes a novel form of the MCIP protein, a 38 kDa version (MCIP-1-38) that predominates in the human heart, the upregulation of which is strongly suggested for the treatment or prevention of heart disease. The present invention provides for methods of treating and preventing cardiovascular diseases, in particular pathological cardiac hypertrophy and chronic heart failure, by applying a modulator of MCIP-1-38. The present invention also provides for methods of screening to find modulators of MCIP-1-38 and inhibitors of cardiac hypertrophy and heart failure.