METHOD FOR SCREENING MULTIPLE SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH SUSCEPTIBILITY OF SPECIFIC DISEASE OR DRUG

摘要

The present invention in each case group and control group the following steps are included: a) select one or more mononucleotide sequences of SNP; B) selection generates one or more of all possible combination by two or more list SNP multiple SNP Genotypings modes formed: single SNP from following steps; C the frequency e genetic patterns of case group and control group) are extracted; And the genotype and institute's lectotype with statistical significance d) are determined in the group of frequency of use; It is related to the multiplex screening method of the meaningful single nucleotide polymorphism in the case where including following group. By the multiplex screening method of single nucleotide polymorphism according to the present invention, it can be securely related to the multiple single nucleotide polymorphism for screening specified disease or drug sensitivity from the whole gene group of individual. ;Multiple single nucleotide polymorphism, Genotyping mode (genetic pattern), odds ratio (odds ratio), verify Fisher(Fisher's precision tests) accuracy