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2ALPHA-METHYL-19-NOR-(20S)-1ALPHA-HYDROXY-BISHOMOPREGNACALCIFEROL AND ITS USES
2ALPHA-METHYL-19-NOR-(20S)-1ALPHA-HYDROXY-BISHOMOPREGNACALCIFEROL AND ITS USES
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机译:2α-甲基-19-NOR-(20S)-1α-羟基-比索莫萘普萘酚及其用途
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摘要
This invention discloses 2alpha-methyl-19-nor-(20S)-vitamin D analogs, and specifically 2alpha-methyl-19-nor-(20S)-1alpha-hydroxy-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
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