The present invention is a sensing of the biological material that the application as a sensor of this development and bio-chip and the microfluidic chip systems applying the biomaterial (sensing), detection, diagnosis, and belongs to the field of gene therapy. ; In developing that Eph Tamer and ribozyme conjugates of Eph batter, in being an Eph batter developed in previous studies and showed the absence of the target substance, self-decomposition, self-decomposition of the ribozyme only when there is in the present invention, the target substance developed an Eph batter any design method - by reaction to produce the animation system (stem) I and designed for fusion (fusion) with the Eph Tamer in stem III, a more sensitive and activated by good. Use them to recognize the real-time as proteins, cells, and biological material by fluorescence in the microfluidic chip system of multiple channels, develop new Eph batter being chip system to make a double through again the mass analyzer to a sensitive material will be. ; Purpose of the invention is a signal as to detect biological material without the noise and develop a biosensor for diagnosis, first, may be used as a sensor that can detect a specific substance with this, the fluorescence when applying it to the biochip to the microfluidic chip, and can be used like a two-dimensional analysis is possible to diagnose and analyze in real time through the mass analyzer. ; This also applies to a specific gene by an external substances through the development of effective design in the study of gene therapy that can be cut is possible. ; Ribozymes, Tamer Ephesians, Ephesians hitter Im bi-hitter Ephesians Lim, biochips
展开▼
