PROCESS FOR THE PREPARATION OF 6,8-SUBSTITUTED '1,7 NAPHTHPYRIDIN DERIVATIVES BY REACTING THE 8-HALO-'1,7 NAPHTHPYRIDIN-DERIVATE WITH AN ORGANIC BORONIC ACID DERIVATIVES AND INTERMEDIATES OF THIS PROCESS

摘要

A process for the manufacture of isoquinoline and 1,7-naphthyridine derivatives of formula wherein RSUB1/SUB, RSUB2/SUB, RSUB3/SUB, RSUB4 /SUBand X have the meanings as indicated in the specification. The process utilizes readily available starting materials of the formulae or compounds prepared from such starting materials wherein RSUB1/SUB, RSUB2/SUB, RSUB3 /SUBand X have meanings as defined for formula (I); and R and RSUB5 /SUBare independently CSUB1/SUB-CSUB7/SUB-alkyl.