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METHODS FOR INCREASING COUMARIN AND SCOPOLETIN CONTENTS IN ARTEMISIA CAPILLARIS, AND THE METHOD FOR EXTRACTION OF COUMARIN AND SCOPOLETIN HAVING INCREASED CONTENTS
METHODS FOR INCREASING COUMARIN AND SCOPOLETIN CONTENTS IN ARTEMISIA CAPILLARIS, AND THE METHOD FOR EXTRACTION OF COUMARIN AND SCOPOLETIN HAVING INCREASED CONTENTS
A method of increasing coumarin and scopoletin contents in Artemisia Capillaris and a method of purifying coumarin and scopoletin in the Artemisia Capillaris are provided, which enables to achieve composition having antioxidant, anti-inflammatory, anticancer and anti-dementia activity. To increase coumarin and scopoletin contents in Artemisia Capillaris, the Artemisia Capillaris is heated at 79.4 to 149.0deg.C for 5 to 30min. The coumarin and scopoletin in Artemisia Capillaris are purified by the steps of: extracting the Artemisia Capillaris having increased coumarin and scopoletin contents with ethanol; dispersing the extract in water, extracting with a solvent selected from the group consisting of dichloromethane and ethyl acetate and concentrating to produce an organic solvent-soluble fraction; and concentrating the organic solvent-soluble fraction and purifying using chromatography. The chromatography uses a solvent selected from the group consisting of methanol, hexane, ethyl acetate, acetic acid, chloroform, benzene and a mixed solvent of two more components thereof and a carrier selected from the group consisting of silica gel, reverse phase silica gel, high speed liquid and Sephadex.
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