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A COMPOSITION FOR TREATING DAMAGE OF CENTRAL OR PERIPHERAL NERVE SYSTEM

机译:治疗中枢或周围神经系统损害的组合物

摘要

A composition comprising neural precursor cell derived from subcutaneous tissue, neuron obtained by differentiating the neural precursor cell, or oligodendrocyte or Schwann cell obtained by differentiating the neural precursor cell is provided to be very useful for treating damage of central or peripheral nerve system by showing excellent accessibility compared to neural stem cell and embryonic stem cell, providing enough donor area for clinical application, becoming more scaled donor source compared to using corium cell and minimizing scar of a donor after donation. The composition for treating damage of central or peripheral nerve system comprises neural precursor cell derived from subcutaneous tissue or neuron obtained by differentiating neural precursor cell derived from subcutaneous tissue or oligodendrocyte or Schwann cell obtained by differentiating neural precursor cell derived from subcutaneous tissue as an effective ingredient, wherein the neural precursor cell forms neurosphere and expresses nestin and/or SOX10, and the damage of central or peripheral nerve system contains Parkinson's disease, stroke, amyotrophic lateral sclerosis, spinal cord injury, motor nerve injury or peripheral nerve traumatic damage.
机译:提供了一种组合物,其包含源自皮下组织的神经前体细胞,通过分化神经前体细胞获得的神经元,或通过分化神经前体细胞获得的少突胶质细胞或雪旺氏细胞,其通过显示优异的效果而对治疗中枢或周围神经系统非常有用。与神经干细胞和胚胎干细胞相比,具有更强的可及性,为临床应用提供了足够的供体面积,与使用真皮细胞相比,供体来源更大,并且最大程度地减少了供体后的疤痕。用于治疗中枢或周围神经系统损伤的组合物包含由皮下组织或通过分化为皮下组织的神经前体细胞获得的少突胶质细胞或雪旺细胞获得的皮下组织或神经元衍生的神经前体细胞作为有效成分。 ,其中神经前体细胞形成神经球并表达巢蛋白和/或SOX10,中枢或周围神经系统的损伤包括帕金森氏病,中风,肌萎缩性侧索硬化,脊髓损伤,运动神经损伤或周围神经损伤。

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