Analytical Techniques of Trace Concentrations of Mequitazine in Human Serum by a Gas Chromatography/Mass Spectrometry with Ion-Trap Detector

摘要

The present invention relates to a blood analysis method mekwi percussion by GC / MS / ITD, in more detail Step into the Promethazine as an internal standard substance in the blood of subjects treated with 1) mekwi percussion; 2) pH of the sodium carbonate was added to an alkaline extraction solvent, hexane, hexane / isopropyl alcohol was added to the step of extracting; And 3) taking the organic solvent layer by centrifugation N ₂ was dissolved in methanol to the residue after evaporation of the gas under the GC / MS /, characterized in that, including the step of injecting the ITD GC / MS / as for the trace analysis of blood mekwi percussion by ITD, the present invention has the advantage of possible analysis of a very small amount is present in the serum concentration of the percussion mekwi a relatively economical high sensitivity and fast analysis times as compared with the conventional method .