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Delivery Agents for Enhancing Mucosal Absorption of Biologically Active Agents
Delivery Agents for Enhancing Mucosal Absorption of Biologically Active Agents
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机译:用于增强生物活性剂的粘膜吸收的递送剂
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摘要
A delivery agent for delivering a biologically active agent to a warm-blooded animal includes a hydrophobic moiety covalently bonded to a hydrophilic moiety. The hydrophobic moiety can include bile acids, sterols, or hydrophobic small molecules. The hydrophilic moiety can include -amino acids, dipeptides or tripeptides, or hydrophilic small molecules. An illustrative delivery agent is N-deoxycholyl-L-lysine-methylester. The delivery agent and the biologically active agent are mixed together to form a complex, which is then administered to the animal. These complexes are particularly useful for oral administration of biologically active agents, but other routes of administration may be used.
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