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3,5-DIHYDROXYBENZOIC ACID DERIVATIVES HAVING ELASTASE INHIBITION EFFECT, THE PREPARATION METHOD THEREOF, AND THE ANTIAGING COSMETIC COMPOSITION CONTAINING THE SAME
3,5-DIHYDROXYBENZOIC ACID DERIVATIVES HAVING ELASTASE INHIBITION EFFECT, THE PREPARATION METHOD THEREOF, AND THE ANTIAGING COSMETIC COMPOSITION CONTAINING THE SAME
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机译:具有弹性蛋白酶抑制作用的3,5-二羟基苯甲酸衍生物,其制备方法以及包含相同成分的抗化妆品成分
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摘要
Provided is a 3,5-dihydroxybenzoic acid derivative, which shows an elastase inhibitory effect and an excellent effect of scavenging free radicals generated by UV irradiation, has an excellent anti-aging effect, and is useful for an anti-aging cosmetic composition. The 3,5-dihydroxybenzoic acid derivative is a compound represented by a formula 1, substituted with hydroxyl groups at 3,5-position thereof and the amide group being substituted with a bulky substituent. The 3,5-dihydroxybenzoic acid derivative is obtained by the method comprising the steps of: (A) reacting 3,5-dihydroxybenzoic acid with acetic anhydride to form 3,5-diacetyloxybenzoic acid; (B) forming an amide compound from the 3,5-diacetyloxybenzoic acid by using ethyl chloroformate and an oleophilic group; and (C) hydrolyzing the acetyl group of the amide compound to provide a 3,5-dihydroxybenzoic acid derivative.
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