3 AN AGENT FOR DIFFERENTIATING HEMATOPOIETIC STEM CELL INTO NATURAL KILLER CELL COMPRISING vitamin D3 AND A METHOD OF DIFFERENTIATING HEMATOPOIETIC STEM CELL INTO NATURAL KILLER CELL USING THEREOF

摘要

The present invention is to control the cell minutes agent and relates to a cell differentiation method, more specifically, VDUP1 (Vitamin D3 upregulating protein 1) protein or a gene or VDUP1 encoding him using a differentiation regulating gene into NK cells in the stem cell in minutes using the same agent, and hematopoietic stem cells containing vitamin D3 as an active ingredient it relates to a method of differentiating into NK cells. VDUP1 gene of the present invention has determined, in the stem cells in the conventional in that is not known to control the differentiation into NK cells genetically, by producing the mice deficient for the gene and differentiation regulation of a natural killer cell, the gene by controlling the differentiation into NK cells in killing tumor cells that function through the regulation it may be useful for anticancer cell therapy. ; Vitamin D3, the natural killer cells topics minutes, hematopoietic stem cells