A system for assessing risk over a life-cycle is provided to calculate a list of chemical substances, and evaluate exposure and the risk of the chemical substances over the life-cycle of the product by receiving information for an inputted material from a user. A material flow analyzing module(100) analyzes a material flow of the product by using an IO(Input/output) analysis of industry relationship. A life-cycle chemical substance list calculating module(200) calculates the list of the chemical substances by using an environment discharge coefficient. An exposure calculating module(300) calculates the exposure of the chemical substances to the human body and the ecosystem. An uncertainty assessment performing module(400) performs uncertainty assessment by using a probability analysis. A risk(500) calculating module for the human body and the ecosystem includes a unit manufacturing process data input module of the target product, a basic data module for calculating a result of the risk assessment, a risk result package module, and a result presenting module.
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