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?-Substituted-1?-quinoline-2,4-diones, preparation method thereof and pharmaceutical composition containing the same

机译：α-取代的-1α-喹啉-2，4-二酮，其制备方法和含有该β-取代的药物组合物

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摘要

The invention N that act as 5-HT6 receptor antagonists - substituted -1 H-quinoline-2,4-dione compounds, methods for their preparation and relates to a pharmaceutical composition for treating central nervous system disorders comprising the same, of the present invention N - substituted -1 H - quinoline-2,4-dione compounds are serotonin 5-HT6 receptor and the binding force of the excellent, and excellent selectivity for the 5-HT6 receptor compared to other receptors, intracellular serotonin (5 as well as to suppress an increase in the concentration of cAMP by -HT), it is effective to suppress the hyperactivity induced in rats by methamphetamine (2 ㎎ / ㎏, ip) useful for central nervous system disorders associated with the 5-HT6 receptor It can be used. ; 5-HT6 receptor antagonists, central nervous system diseases

机译：用作5-HT 6受体拮抗剂的本发明 N -取代的-1 H-喹啉-2,4-二酮化合物，其制备方法和涉及药物组合物用于治疗包括中枢神经系统疾病的本发明的 N -取代的-1 H -喹啉-2,4-二酮化合物是5-羟色胺5-HT6受体和与5-HT6受体相比，对细胞内5-羟色胺具有极好的选择性，对5-HT6受体具有极好的选择性（5以及抑制-HT引起的cAMP浓度增加），可有效抑制诱导的过度活跃在大鼠中通过甲基苯丙胺（2㎎/㎏，ip）对与5-HT6受体相关的中枢神经系统疾病有用，可以使用。 ; 5-HT6受体拮抗剂，中枢神经系统疾病 展开▼

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公开/公告号KR100753905B1

专利类型

公开/公告日2007-08-31

原文格式PDF

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申请/专利号KR20050111634

发明设计人 성철민;박노상;최진일;박우규;공재양;조희영;강선희;송석진;
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申请日2005-11-22

分类号C07D401/04;C07D401/14;

国家 KR

入库时间 2022-08-21 20:31:29

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