The vaccine strains of influenza virus A / 17 (CA) 4.6 (H3N2) and attenuation donor (Leningrad) 134/17 / K7 / 57 (N2N2) to obtain it

摘要

1. the strain of influenza virus a / 17 (u043au0430u043bu0438u0444u043eu0440u043du0438u00a0) 04 / 6 (H3N2) u0433u0438u0441u043a u2116146 (national institute of standards and u043au043eu043du0442u0440u043eu043bu00a0 name u043b.u0430.u0442u0430u0440u0430u0441u0435u0432u0438u0447u0430) used u0434u043bu00a0 u043fu043eu043bu0443u0447u0435u043du0438u00a0 alive gris u043fu043fu043eu0437u043du043eu0439 u0438u043du0442u0440u0430u043du0430u0437u0430u043bu044cu043du043eu0439 vaccine u0434u043bu00a0 u0434u043bu00a0 adults and children.;2. the donor u0430u0442u0442u0435u043du0443u0430u0446u0438u0438 u0434u043bu00a0 production u0432u0430u043au0446u0438u043du043du043eu0433u043e strain in 1 and (leningrad) 134 / 17 / u043a7 / 57 (H2N2), a clone of the virus and u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u044eu0449u0438u0439 (leningrad) 134 / 17 / 57 (H2N2) with seven significant mutations in the internal genes: u0440u04322 (val - 478 - leu), u0440u04321 (Lys - 265 - Asn and val 591 - le), pa (leu - 28 - pro and val - 341 - leu), m1 (le - 15 - val) and NS2 (met - 100 - le).