HUMAN MELANOMA CELLULAR LINE mel Kor USED IN PREPARING ANTITUMOR VACCINE

摘要

FIELD: biotechnology, oncology.;SUBSTANCE: invention relates to a novel prepared human melanoma cellular line mel Kor that possesses stable cultural and morphological indices and stored in the Specialized collection of cellular cultures of Cytology institute at number PKKK (P) 687D. The cellular line is characterized by expression of melanoma (differentiating) markers - CD-63, HMB-45, HMW, MelanA and Tyrozinaza and cancer-testicular marker MAGE-3 also and absence of histo-compatibility antigens of the first and the second class. The cellular line can be used for creature of antitumor (all-cell, genetic engineering) vaccines used in treatment of melanoma and other malignant neoplasms. Using the invention provides preparing the novel effective antitumor vaccine and can be used in medicine for vaccine therapy of malignant neoplasms.;EFFECT: valuable medicinal properties of cellular line.;1 tbl, 2 ex