首页> 外国专利> USING COMPOUND COMBINING PROPERTY OF SEROTONIN REVERSE UPTAKE INHIBITOR AND AGONIST OF 5-HT1A-RECEPTOR

USING COMPOUND COMBINING PROPERTY OF SEROTONIN REVERSE UPTAKE INHIBITOR AND AGONIST OF 5-HT1A-RECEPTOR

机译:利用5-HT 1A 受体的5-羟色胺逆向吸收抑制剂和激动剂的复合性能

摘要

FIELD: organic chemistry, veterinary science.;SUBSTANCE: invention relates ton using a compound combining properties of inhibitor of serotonin (5-HT) reverse uptake and agonist of 5-HT1A-receptors as an agent used in treatment of disorders associated with behavior stressors in veterinary medicine. Indicated compound is chosen from the group consisting of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)-piperazine or its physiologically acceptable salt or 3-{4-[4-(4-cyanophenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile or its physiologically acceptable salt. Invention provides higher level of inhibition of indicated disorders in animals as compared with the known analogues.;EFFECT: improved and valuable medicinal and veterinary properties of compound.;4 cl, 3 ex
机译:领域:本发明涉及使用5-羟色胺(5-HT)反向摄取抑制剂和5-HT 1A -受体激动剂的特性相结合的化合物作为试剂兽医中与行为应激源相关的疾病的治疗。所指示的化合物选自1- [4-(5-氰基吲哚-3-基)丁基] -4-(2-氨基甲酰基苯并呋喃-5-基)-哌嗪或其生理上可接受的盐或3- {4- [4-(4-氰基苯基)-哌嗪-1-基]-丁基} -1H-吲哚-5-腈或其生理上可接受的盐。与已知的类似物相比,本发明提供了更高水平的对动物所指示疾病的抑制。效果:化合物的改进的和有价值的医学和兽医特性。4 cl,3 ex

著录项

  • 公开/公告号RU2288719C2

    专利类型

  • 公开/公告日2006-12-10

    原文格式PDF

  • 申请/专利权人 MERK PATENT GMBKH;

    申请/专利号RU20030115431

  • 发明设计人 GERD BARTOSHIK (DE);

    申请日2001-10-16

  • 分类号A61K31/495;A61P25/18;

  • 国家 RU

  • 入库时间 2022-08-21 20:30:45

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