ANTITUMOR REMEDY TAKEN PER OS AND METHOD FOR PRODUCING THE REMEDY

摘要

FIELD: medicine.;SUBSTANCE: preparation belongs to gestagen class as 17^α-acetoxy-3β-butanoyloxy-6-methyl-pregna-4,6-dien-20-on allowing peroral application. The compound shows no toxic activity and has no androgenic side effect. It is found to be better than Depo-Provera gestagen used in clinical practice and possesses chemosensitizing activity. The preparation is obtained by megestrol acetate reduction with sodium borohydride with following product etherification with butyric acid anhydride. The reaction mixture is treated with ammonia solution after etherification with butyric acid excess being removed to increase output and target product separation.;EFFECT: enhanced effectiveness of treatment.;3 cl, 3dwg, 1 tbl