METHOD FOR LOCALLY SUPPRESSING ANGIOGENESIS IN TARGET TISSUE

摘要

FIELD: medicine; biology.;SUBSTANCE: method involves introducing vector containing DNA-sequence into area under protection encoding T-cadgerin and being capable of providing its expression in target tissue or cells compatible with target tissue cells transected with said vector in advance and selected with respect to T-cadgerin expression level. The method has been tested on model system by implanting Matrigel to mice. Reliable implant mass-, implant hemoglobin contents- and capillary and medium-sized blood vessel number reduction has been observed in experimental animals, receiving cells L929 (clone TC3) expressing T-cadgerin, in two weeks after the injection.;EFFECT: enhanced effectiveness in treating pathological states with new blood vessel formation being suppressed.;7 cl, 8 dwg