DIBENZYLAMINE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND THERAPEUTIC OR PROPHYLACTIC AGENT BASED ON THEREOF, METHOD FOR TREATMENT OR PROPHYLAXIS OF HYPERLIPIDEMIA OR ARTERIOSCLEROSIS

摘要

FIELD: organic chemistry, medicine, pharmacy.;SUBSTANCE: invention relates to dibenzylamine compounds of the formula (1): wherein each among R¹ and R² represents (C₁-C₆)-alkyl group optionally substituted with halogen atoms and so on; each among R³, R⁴ and R⁵ represents hydrogen atom, halogen atom and so on, either R³ and R⁴ in common with carbon atoms bound to them can form a carbocyclic or heterocyclic ring optionally having a substitute (substitutes); A represents -N(R⁷)(R⁸) and so on; ring B represents aryl group or heterocyclic residue; R⁶ represents hydrogen atom, halogen atom, (C₁-C₆)-alkyl group and so on; n means a whole number from 1 to 3, or its pharmaceutically acceptable salt. Proposed compounds elicit the selective and strong inhibitory effect on CETP activity and can be used as therapeutic or prophylactic agents against hyperlipidemia or arteriosclerosis. Also, the proposed compound can be used with other pharmaceutical agent or some pharmaceutical agents simultaneously against hyperlipidemia or arteriosclerosis. Invention provides the development of a pharmaceutical composition based on dibenzylamine compounds used in treatment or prophylaxis of hyperlipidemia or arteriosclerosis.;EFFECT: valuable medicinal properties of compound and pharmaceutical composition.;25 cl, 40 tbl, 174 ex