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NOVEL BIOTECHNOLOGICALLY CREATED SUPERANTIGEN FOR TREATING HUMANS
NOVEL BIOTECHNOLOGICALLY CREATED SUPERANTIGEN FOR TREATING HUMANS
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机译:新型生物技术创造的人类上乘抗原
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FIELD: oncology and biotechnology.;SUBSTANCE: invention concerns conjugates used for treatment of malignant tumor. Conjugate includes staphylococcal or streptococcal wild-type superantigen or modified superantigen and antibody constituent. Bacterial superantigen is modified to reduce serum reactivity with preserved its antigenic activity. Amino acid sequence of superantigen incorporates A-E regions determining binding to TCR and MHC molecules class II. Invention is directed to preparing antitumor drug and also to preparing pharmaceutical composition.;EFFECT: use of the conjugate according to invention activate immune system and, therefore, resistance of mammalian against malignant tumor.;67 cl, 11 dwg, 1 tbl, 11 ex
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机译:领域:发明涉及用于治疗恶性肿瘤的缀合物。缀合物包括葡萄球菌或链球菌野生型超抗原或修饰的超抗原和抗体成分。修饰细菌超抗原以降低血清反应性,同时保留其抗原活性。超抗原的氨基酸序列掺入了A-E区,该区决定了与TCR和II类MHC分子的结合。本发明涉及制备抗肿瘤药以及制备药物组合物。效果:根据本发明的缀合物的使用激活了免疫系统,因此激活了哺乳动物对恶性肿瘤的抵抗力; 67 cl,11 dwg,1 tbl,11 ex
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