A method for the model-based on - line optimization and parameter estimation of batch - chromatography processes

摘要

A method for the control and monitoring of batch - chromatography processes a chromatographic column, which as a result of the operating parameters batch size, solution means flow, solvent composition, batches of distance, switching times of fractionated is determined, two valves, with a detector for the analysis of the emerging eluents at the output, whereby for the process control and monitoring a physically - chemically reasoned dynamic mathematical model of the chromatographic column, the isothermal - and the fabric transport parameters and dispersion coefficient as a significant parameter, is used,characterized in that– the significant parameters of this model of the information of the detector by minimizing an error function be newly determined online– the model on the basis of the newly defined significant parameters is adapted to and from this online the operating parameters of the chromatographic column are determined, and in that– these operating parameters to the chromatographic separation column is set or to be monitored.