首页>
外国专利>
Transdermal therapeutic system, for skin application, comprises backing that is impermeable for active substance, two polymer matrix layer, removable protective layer, donor layer, optionally an additional matrix layer and back layer
Transdermal therapeutic system, for skin application, comprises backing that is impermeable for active substance, two polymer matrix layer, removable protective layer, donor layer, optionally an additional matrix layer and back layer
Transdermal therapeutic system comprising at least an easily volatile and/or thermolabile active substance and/or auxiliary material, comprises a backing, which is basically impermeable for the active substance and the auxiliary material; at least two polymer matrix layer, from which at least one serves as an acceptor layer, comprising active substance and/or auxiliary material; a removable protective layer; a donor layer; optionally an additional matrix layer and a back layer. Transdermal therapeutic system comprising at least an easily volatile, thermolabile active substance and/or auxiliary material, comprises a backing, which is basically impermeable for the active substance and the auxiliary material; at least two polymer matrix layer, from which at least one serves as an acceptor layer, containing active substance and/or auxiliary material; a removable protective layer; a donor layer; optionally an additional matrix layer and a back layer, where the transdermal therapeutic system is produced by sequence laminate coating of removable protective layer, at least one skin-sided arranged polymer matrix layer, further an polymer acceptor layer, which is incorporated with volatile, thermolabile active substance and/or accelerated auxiliary material, where during lamination or within short time after lamination, the donor layer combines with the acceptor layer by migration of the volatile, thermolabile and/or auxiliary material. An independent claim is included for a procedure for producing transdermal therapeutic system comprising preparing the volatile and/or thermolabile active substance and/or auxiliary material either alone or in combination with other auxiliary material; preparing an acceptor layer by coating or drying the active substance mixture; applying on the donor layer, in which the coated acceptor layer is covered with a back layer or first with an anchor layer and with an back layer, so that the prepared laminate combines with at least one on the opposite side provided with a removable layer (releasing liner) matrix.
展开▼